Intuitively, and ideally, patients, donors, and transplant physicians should know the requirements for, and the potential risks and benefts of hematopoietic stem cell transplant (HSCT) before they agree in a joint decision to proceed with a transplant procedure. Is there a reasonable chance for long-term survival with an acceptable quality of life compared with other therapeutic options? Has everything been undertaken to minimize the risks for the donor, whose beneft is solely altruistic? Is suffcient infrastructure available for the complex HSCT procedure, and will the costs be covered? As obvious as these questions are, answering them requires a great deal of information.