Clinical Practice Points: • DCIS is an elusive and misleading disease, mostly because its natural history is poorly understood. • The entire process progresses over time under endogenous and exogenous influences, not like a photo, but like a lifelong movie. • AClinical Practice Points: • DCIS is an elusive and misleading disease, mostly because its natural history is poorly understood. • The entire process progresses over time under endogenous and exogenous influences, not like a photo, but like a lifelong movie. • Actually we have a rough outline of space where the changes arise and know almost nothing about times which are likely to occur. • Some so-called unexpected events are more likely underestimated. • New theories of sick lobe and biological time place different patterns of disease into a unifying concept with genetic and developmental perspectives of understanding. ctually we have a rough outline of space where the changes arise and know almost nothing about times which are likely to occur. • Some so-called unexpected events are more likely underestimated. • New theories of sick lobe and biological time place different patterns of disease into a unifying concept with genetic and developmental perspectives of understanding.