In this chapter, the manner a new drug is discovered and selected as well as the costs, challenges and risks around the selection of a candidate molecule are discussed. As candidate quality impacts attrition in later phases of development this concept is developed as well. The aim is to frame the key aspects of drug candidate selection in general to place into context the challenges that a drug discovery team would face for the selection of a dermal drug candidate. Finally, specifc risks and opportunities for selecting such a dermal drug candidate are presented.