توضیحات
ABSTRACT
Protein subcellular localization (PSL), as one of the most critical characteristics of human cells, plays an important role for understanding specific functions and biological processes in cells. Accurate prediction of protein subcellular localization is a fundamental and challenging problem, for which machine learning algorithms have been widely used. Traditionally, the performance of PSL prediction highly depends on handcrafted feature descriptors to represent proteins. In recent years, deep learning has emerged as a hot research topic in the field of machine learning, achieving outstanding success in learning high-level latent features within data samples. In this paper, to accurately predict protein subcellular locations, we propose a deep learning based predictor called DeepPSL by using Stacked Auto-Encoder (SAE) networks. In this predictor, we automatically learn high-level and abstract feature representations of proteins by exploring non-linear relations among diverse subcellular locations, addressing the problem of the need of handcrafted feature representations. Experimental results evaluated with 3-fold cross validation show that the proposed DeepPSL outperforms traditional machine learning based methods. It is expected that DeepPSL, as the first predictor in the field of PSL prediction, has great potential to be a powerful computational method complementary to existing tools.
INTRODUCTION
Knowledge of the subcellular localization of proteins is critical for the understanding of their functions and biological processes in cells. Proteinsubcellular location information is of highly importance in various areas of research, such as drug design, therapeutic target discovery, and biological research, etc . Accurate prediction of rotein subcellular localization is the prequiste to help in-depth understanding and analysis of various protein
functions.
Year: ۲۰۱۸
Publisher : ELSEVIER
By : Leyi Wei, Yijie Ding, Ran Su, Jijun Tang, Quan Zou
File Information: English Language/ 19 Page / size: 981 KB
سال : ۱۳۹۶
ناشر : ELSEVIER
کاری از : لی وی، ییجی دینگ، ران سو، جیجون تانگ، کوانوز زو
اطلاعات فایل : زبان انگلیسی / 19 صفحه / حجم : KB 981
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