What is this term and why is it important for the use of this book? Even though this book is a biological psychopharmacology handbook, it is based on the foundation that the prescriber is generally a good human being who cares about the patient and wants to form a partnership and alliance with the patient in order to get them better. To maximize patient adherence and compliance with medications and to improve visit attendance and session productivity, the core skills of psychotherapy are needed. To maximize the tolerance of known side effects and to diminish the effects of placebo induced side effects (nocebo effects), the core skills of supportive psychotherapy are needed. If the prescriber loses track or does not deploy these skills while prescribing, the author suspects that outcomes will be worse than those advertised.