Tissue engineering is an interdisciplinary field that utilizes cells, biomaterials, biochemical (e.g., growth factors) and physical (e.g., mechanical loading) signals, as well as their combinations to generate tissue-like structures . Te goal of tissue engineering is to provide biological substitutes that can maintain, restore, or improve the function of damaged tissues . Although the first tissue-engineered skin products were introduced in the late 1970s and early 1980s giving rise to modern tissue engineering, the term “tissue engineering” was coined only in 1987 . In fact, the use of prosthesis (e.g., gold for tooth replacement and wood for limbs and toes) was employed as early as ancient Egyptians. However, these treatments were all based on nonliving materials, which provided some structure and function but were very far from the original tissue. Medical development led ,in the middle of the twentieth century, to the possibility of replacing an entire organ with an organ from a donor, known today as organ transplantation . Although this is widely practiced today and is known to be the ultimate solution for organ failure, the need for organs always surpasses the number of available donated organs . Te limited donor availability and rejection of the grafts by the immune system drove the concept of in vitro grown tissues. Te success in tissue engineering of skin grafts boosted the interest in applying similar concepts to other tissues and organs.