بایگانی برچسب برای: Dermatology

Emergency.Dermatology.Second.[taliem.ir]

Emergency Dermatology

When cells are damaged, as often occurs during trauma and metabolic stress, the organism has to choose whether to repair the damage by promoting cell survival or to remove irreparably injured cells. Cell injury occurs when an adverse stimulus reversibly disrupts the normal, complex homeostatic balance of the cellular metabolism. In this case, after injury the cellsattempt to seal breaks in their membranes, chaperone the removal or refolding of altered proteins, and repair damaged DNA. On the contrary, when cell injury is too extensive to permit reparative responses, the cell reaches a “point of no return,” and the irreversible injury culminates in programmed cell death (PCD). Specific properties or features of cells make them more or less vulnerable to external stimuli, thus determining the kind of cellular response. In addition, the characteristics of the injury (type of injury, exposure time, or severity) will affect the extent of the damage. We present a short overview of the best-known PCD pathways. We emphasize the apoptotic pathway, considered for years the hallmark of PCD, and the different stimuli that produce cell injury.
Angiogenesis-Based[taliem.ir]

Angiogenesis-Based Dermatology

This book is dedicated to the memory of Judah Folkman, MD, with whom I had the pleasure of spending a 4-year postdoctoral fellowship, between the years 1994 and 1998. There are several aspects to Dr. Folkman’s personality that made him so effective in advancing angiogenesis in medicine. First, his research was clinically driven. He wanted to use angiogenesis as a tool to cure human disease. Thus, he chose to use basic research to address clinical problems, not as an end to itself. There are two camps of people who perform basic research with regard to human disease. The frst believes that we have to know everything in order to treat human disease. A corollary of that belief is that once we know everything, we will be able to design a specifc targeted therapy that cures advanced cancer or other ailment, with no side effects. This will be accomplished because advanced cancers are addicted to an oncogene, and targeting that oncogene will lead to a painless cure. The second camp is the one that Dr. Folkman belonged to, in that he wanted to know how we could leverage the knowledge that we have today to help patients who are sick today. As a pediatric surgeon, he recognized that patients who are sick today need treatments today, and will likely not survive until that utopian time that we have magic bullets with no side effects.