The International Society of Reconstructive Neurosurgery (ISRN) is an “open” multidisciplinary Society in evolution. Many different members of the Society inspire new trends in many different neurosurgical felds, all dealing with neurosurgical reconstruction. Spine and peripheral nerve reconstructive surgery, central nervous system revascularization (via surgery and interventional radiology), neuromodulation, bioengineering, and transplantation are recent tools used to promote reconstruction, restoration, and rehabilitation. These are the three key words of our creed and all fulfll the aim of the ISRN, dealing with mechanical, morphological, and functional restoration. Spinal, functional, vascular, radiological, and oncologic neurosurgeons are those to whom our proposals are addressed, along with biologists, bioengineers, anatomists, physiologists, and physiotherapists, who are precious and irreplaceable inspirers.