Obesity is now a well-established promoter of cancer progression and decreased overall patient survival. Ever since the association between obesity and cancer was appreciated, adipose tissue, adipocytes, and secreted fat-derived factors have been a focus of the mechanism underlying this link. Adipose-secreted factors cytokines are referred to as adipocytokines and represent the group of molecules thought to link adipose or fat cells to initiation and promotion of various cancers. There are over 20 identified adipokines, of which, a subset has been implicated in cancer. In this chapter, we will provide a concise review of the current literature on the subset of adipose-derived factors linked to cancer.