توضیحات
ABSTRACT
Antimicrobial peptides (AMP) are a promising source of antibiotics with a broad spectrum activity against bacteria and low incidence of developing resistance. The mechanism by which an AMP executes its function depends on a set of computable physicochemical properties from the aminoacid sequence. The Peptides package was designed to allow the quick and easy computation of ten structural characteristics own of the antimicrobial peptides, with the aim of generating data to increase the accuracy in classification and design of new amino acid sequences. Moreover, the options to read and plot XVG output files from GROMACS molecular dynamics package are included.
INTRODUCTION
Antimicrobial peptides are a promising source of antibiotics with a broad spectrum activity against bacteria and low incidence of developing resistance (Hancock, 2001). Multiple research has concluded that the natural biological activities of these peptides are coordinated by a sophisticated modulation of the hydrophobicity, amphipathicity, positive charge and a reduction in the hydrophobic moment (Yeaman and Yount, 2003; Fjell et al., 2012; Matsuzaki, 2009). Additionally to these four properties there are other descriptors that used in conjunction can provide useful information in the classification and design of antimicrobial peptides (Boman, 2003; Wang et al., 2009; Thomas et al., 2010; Piotto et al., 2012). The computation of these properties for antimicrobial peptides is available free of charge through various web or native applications as ExPASy-protparam (Gasteiger et al., 2005), EMBOSS-pepstats (Rice et al., 2000), BioPerl (Stajich et al., 2002), CAMP (Thomas et al., 2010) and APD (Wang et al., 2009) databases. However, no application allows the computation of all properties. Some of these services allow only the computation of some properties for a sequence at a time, and have no option for downloading and handling this information in editable files. Others allow the calculation of more than one sequence, but they write an output file for each one of them, which makes it difficult to handle and analyse the data.
Year:2015
Publisher: ISSN
By: Daniel Osorio, Paola Rondón-Villarreal and Rodrigo Torres
File Information:English Language/ 11Page / size:292KB
Download:click
سال :2015
ناشر : ISSN
کاری از : Qiankun Zhao , Sourav S Bhowmick
اطلاعات فایل : زبان انگلیسی / 20صفحه / حجم : 243KB
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