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Adipocytokines, Energy Balance, and Cancer

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Adipocytokines, Energy Balance, and Cancer

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Obesity is now a well-established promoter of cancer progression and decreased overall patient survival. Ever since the association between obesity and cancer was appreciated, adipose tissue, adipocytes, and secreted fat-derived factors have been a focus of the mechanism underlying this...

Cancer and Chemoprevention: An Overview

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Cancer and Chemoprevention: An Overview

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Cancer is a cluster of diseases which involves variation in the status and activation of multiple genes that  impart an advantage to survive and unexhausting proliferative potential to somatic or germinal cells (Cho  2007). The three main classes of genes...

Current and Emerging Therapies in Pancreatic Cancer

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Current and Emerging Therapies in Pancreatic Cancer

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Pancreatic cancer (PC) is one of the leading causes of cancer deaths worldwide. It is the fourth leading cause of cancer-related death in both men and women in the United States and has <10% 5-year overall survival rate for all...

Development of Oral Cancer

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Development of Oral Cancer

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Oral cancer is a major health burden particularly in the developing world where most of the cases are diagnosed . More than 300,000 new patients are estimated to be diagnosed with oral and oropharyngeal cancer in 2012, and 50% of...

Early Phase Cancer Immunotherapy

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Early Phase Cancer Immunotherapy

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While connoting both the social as well as biological consequences of an entity that has plagued mankind for millennia, this sentiment recognizes the central role of the immune system in wound healing, or, in this  context, tumor elimination. The critical...

Immunotherapy for Gastrointestinal Cancer

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Immunotherapy for Gastrointestinal Cancer

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More than a century ago, the Nobel Prize for Physiology or Medicine (1908) was awarded jointly to Ilya Mechnikov and Paul Ehrlich “in recognition of their work on immunity” and it was around this time that Ehrlich expounded his hypothesis...

Liquid Biopsy in Cancer Patients

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Liquid Biopsy in Cancer Patients

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In recent years the treatment of cancer patients has profoundly changed, thanks to the study and the  comprehension of the biological processes underlying tumor development and progression. Almost 20 year ago was first  used the term “oncogene addiction ” to...

Male Breast Cancer

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Male Breast Cancer

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There is substantial evidence of deleterious health behaviour in males both in terms of high-risk activities and avoidance of contact with doctors. This manifests as delay in diagnosis and upstaging of disease with a  consequent worsening of prognosis. The incidence...

Minimally Invasive Surgery for Upper Abdominal Cancer

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The postoperative advantages of the Minimally Invasive Surgical (MIS) approach in comparison with Open approach in Upper Gastrointestinal Oncology concern: (1) The stress and immune responses, (2) the surgical intervention, (3) the postoperative short-term effects and morbidity, (4) the postoperative...
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