Showing 1–12 of 46 results
A double-blind controlled study of a nonhydroquinone bleaching cream in the treatment of melasma
Background Melasma iرایگان!
Background Melasma is an acquired hypermelanosis predominantly affecting the face of women. It is often recalcitrant to treatment with hypopigmenting agents. Objective To assess the efficacy of a nonhydroquinone cream (Amelan M®) vs. another (Mela-D®) as treatment for melasma. Methods Twenty-two French women with bilateral epidermal and/or mixed melasma were enrolled in a split-faced prospective trial lasting 4 months during summer season weeks. Twelve patients applied once-daily Amelan M® to one side of the face with sun-protective factor 60 UVA sunscreen each morning and Mela-D® once-daily to the other side of the face. Pigmentation was measured objectively using a mexameter and the melasma area and severity index (MASI) were measured subjectively. Results The mean decrease of pigmentation was statistically significant on the MASI with both cream and only with Amelan M with the mexameter. Some adverse side effects were observed. Conclusions Amelan M® is really more effective than Mela D® cream on melasma. Even though some side effects were observed patients preferred the Amelan M-treated side.
A New Approach to Stone-reliefs of Persepolis
In the north easternرایگان!
In the north eastern part of the Persian Gulf in Iran, there is a region called Fars today and Parse in the past. In this mountainous region there is a mountain previously called Mehr (love) and now called Rahmat (Mercy) with a 2500 years old ruined palace still dazzling on its skirts, remaining from the Achaemenid reign over Iran from c.550 to 330BC. Despite considerable research on the religion of this dynasty, Iranologists have not still conclusively reached a definite opinion on this matter and if they have, it is based on questionable evidences and interpretations. Based on remaining inscriptions and stone-carvings of this monument, the article is an attempt to show that the kings of this dynasty were definitely followers of Zoroaster, who founded the first official religion of the world 6 to 7 centuries AD, with all the symbols found in this unique palace having Iranian roots which so far have wrongly been attributed to the beliefs of other peoples and civilizations.
A practical, algorithmic approach to diagnosing hair shaft disorders
The hair shaft is aرایگان!
The hair shaft is a unique structure composed of an inner cortex and a protective outer cuticle. Any defects in this normal structure due to genetics or the environment can lead to variations in physical properties. Thus one should suspect a hair shaft disorder if a patient presents with an abnormality or change in hair texture, appearance, manageability or ability to grow hair long. A key feature of the clinical evaluation is to determine whether there is hair breakage (increased fragility) by looking for broken hairs and performing a tug test. Once this determination is made, an algorithmic approach can be used to narrow the differential diagnosis: hair shaft disorders with and without fragility. A hair mount along with other directed questions and examination will almost always allow the clinician to make an in-office diagnosis. Common case scenarios, photographs, and practical tips are provided to illustrate the use of this algorithmic approach in the diagnosis of hair shaft disorders. We have also included a summary of the molecular defects where known, which can be helpful in providing a correlation with clinical findings, in counseling patients, and potentially offering treatment options.
A review of nanotechnological approaches for the prophylaxis of HIV/AIDS
Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than
33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV
infection have been reported
Abnormalities in the Adrenergic Control and the Rate of Lipolysis in Isolated Human Subcutaneous Adipose Tissue in Diabetes Mellitus
Subcutaneous adipose tissue was obtained from 9 patients with untreated diabetes mellitus and from 13 obese nondiabetics. After incubation with isoprenaline or noradrenaline, glycerol release and tissue cyclic AMP (cAMP) were determined. Basal glycerol release was twice as rapid from the diabetic adipose tissue. With isoprenaline, the cAMP concentration and the glycerol production was significantly higher in the diabetic adipose tissue. Noradrenaline did not increase glycerol production or cAMP concentration in the diabetic adipose tissue. Subcutaneous adipose tissue was also removed from the diabetics after antidiabetic treatment. Basal lipolysis was significantly reduced and noradrenaline significantly increased both glycerol release and cAMP production. With isoprenaline, cAMP production and glycerol release were significantly less after antidiabetic treatment than in the untreated state. The data provide evidence for increased a- as well as fl-adrenergic receptor sensitivity in human subcutaneous adipose tissue of untreated diabetic patients.
Alzheimer’s disease: synaptic dysfunction and Aβ
Synapse loss is an eرایگان!
Synapse loss is an early and invariant feature of Alzheimer’s disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed that synapse loss underlies the memory impairment evident in the early phase of AD and that since plasticity is important for neuronal viability, persistent disruption of plasticity may account for the frank cell loss typical of later phases of the disease. Extensive multi-disciplinary research has implicated the amyloid β-protein (Aβ) in the aetiology of AD and here we review the evidence that non-fibrillar soluble forms of Aβ are mediators of synaptic compromise. We also discuss the possible mechanisms of Aβ synaptotoxicity and potential targets for therapeutic intervention.
Analysis of anti –inflammatory active fractions of Tribulus terrestris by high resolution GC-MS
High resolution GC-Mرایگان!
High resolution GC-MS Analysis of anti –inflammatory active fractions of Tribulus terrestris have been studied. The phytoconstituents of the anti –inflammatory active fractions of Tribulus terrestris were investigated using Thermo Scientific TM DFS high resolution GC-MS Thermo fisher scientific Inc. The GC-MS analysis revealed the existence of 25 compounds, some of them with either known antiinflammatory activity or shows another activities strongly related to the inflammation process.
Appetite and gastrointestinal motility: Role of ghrelin-family peptides
Eating disorders, obرایگان!
Eating disorders, obesity and cachexia endanger the lives of millions of people worldwide. Fortunately, in last decade, there has been a rapid and substantial progress toward uncovering the molecular and neural mechanisms by which energy imbalance develops. In 1999, ghrelin was identified as the first orexigenic gut-derived peptide. It stimulates appetite and controls the gastric motility and the acid secretion through the activation of the growth hormone secretagogue-receptor. After the discovery of ghrelin, other forms of ghrelin-related proteins were isolated from the rat stomach. The unmodified des-noctanoyl form (des-acyl ghrelin) and the recent obestatin act through distinct receptors and contrarily to acyl ghrelin, show an anorexigenic activity. The finding that these three peptide hormones derive from the same precursor exert opposing physiological actions, highlights the importance of post-translational regulatory mechanisms. Further investigations are required to highlight the complexity of ghrelin physiology in order to better understand the mechanisms regulating the energy balance and provide a successful treatment of eating disorders, obesity and cachexia.
Application of Embedded System for Sightless with Diabetes
For sightless or weaرایگان!
For sightless or weak-eyed people with diabetes is impossible to read the actual information showed on any displays. Especially personal diagnostic systems for glucometery measurement are vital important. Those who are sightless need a help of another person at disposal when measuring. The paper presents design and application of an electronic embedded system to enables a purblind or a sightless people to identify measured data and use them suitable for the further treatment processes. The described system can be used in connexion with any diagnostics system disposing data interface. The purblind or sightless people will be able to perform selfmonitoring (observation of disease trend and a dosage adjustment by a person himself).
Auxiliary-Carrier Load-Shift Keying for Reverse Data Telemetry from Biomedical Implants
This paper introduceرایگان!
This paper introduces a new approach for data telemetry from biomedical implantable devices to the external world (also known as reverse data telemetry). In the proposed approach, while power (and perhaps data) is transferred to the implant using a main carrier, a second carrier is also sent to the implant through the same link. The second carrier, which is of higher frequency and smaller amplitude, is envisioned for reverse data telemetry by load-shift keying. In this work, the wireless link is realized with two resonant frequencies using closely-coupled printed spiral coils and LC matching networks. The main and auxiliary carrier frequencies are 1MHz and 10MHz with 5V and 1V peak amplitudes, respectively. While the link is capable of continuously supplying unregulated power of up to 80mW at 4V(peak) to a 100-Ω resistive load, data telemetry at a rate of 100 kbps is successfully tested in the reverse direction.
Bladder Pain Syndrome – An Evolution
Dr. Guy LeRoy Hunnerرایگان!
Dr. Guy LeRoy Hunner, 1868–1957, a Johns Hopkins gynecologist, in a paper delivered to the Boston Medical Society described the ‘Hunners Ulcer’ in 1915. Seventy years later, in 1985 the idea of bringing together experts in the feld of interstitial cystitis led to an assemblage following the 1986 International Continence Society meeting in Boston. This meeting was a unique opportunity to take advantage of the attendance and willingness of most of the authors who were internationally recognized in the feld, and who eventually contributed to the frst edition published in 1990. Twenty-seven years is a long time between editions. Much has changed. Books and journals are no longer on library shelves, but exist in the ether. Much has not changed. Only two drugs are approved by the Food and Drug administration to treat IC/BPS, both of which were available when the frst edition was printed. We think it is time to take a look back at how the feld has advanced given the millions of dollars in research that have been devoted to it and the world-wide interest in the disorder that propelled the prevalence data from an estimated 40/100,000 to a current estimate of greater than 2700/100,000. What have we learned in the last 30 years, where are we now, and how can we best advance the feld forward?
Capability maturity models for offshore organisational management
The goal setting regرایگان!
The goal setting regime imposed by the UK safety regulator has important implications for an organisation’s ability to manage health and safety related risks. Existing approaches to safety assurance based on risk analysis and formal safety assessments are increasingly considered unlikely to create the step change improvement in safety to which the offshore industry aspires and alternative approaches are being considered. One approach, which addresses the important issue of organisational behaviour and which can be applied at a very early stage of design, is the capability maturity model (CMM). The paper describes the development of a design safety capability maturity model, outlining the key processes considered necessary to safety achievement, definition of maturity levels and scoring methods. The paper discusses how CMM is related to regulatory mechanisms and risk based decision making together with the potential of CMM to environmental risk management.